Hybrid Method of Non-invasive Intracranial Pressure Measurement Using Autoencoder Neural Network Algorithm |
| M. Bohdanowicza, D. Cardimb, B. Schmidtc, F. Wadehnd, M. Nałęcza, M. Rupniewskia, D.J. Kime, f, M. Czosnykag
aInstitute of Electronic Systems, Warsaw University of Technology, Nowowiejska 15/19, 00-665 Warsaw, Poland bDepartment of Neurology, University of Texas Southwestern Medical Centre, 5323 Harry Hines Blvd., TX 75390, Dallas, Texas, United States of America cNeurology Klinikum Chemnitz, Dresdner Straß e 178, 09131 Chemnitz, Germany dInstitute of Signal Processing and Wireless Communications, Zurich University of Applied Sciences, Technikumstrasse 9, 8401 Winterthur, Switzerland eDepartment of Brain and Cognitive Engineering, Korea University, 145 Anam-ro Seongbuk-gu, 02841 Seoul, Republic of Korea fDepartment of Neurology, Korea University Anam Hospital, Korea University College of Medicine, 73 Goryeodae-ro Seongbuk-gu, 02841 Seoul, Republic of Korea gDivision of Neurosurgery, Department of Clinical Neurosciences, University of Cambridge, Addenbrooke's Hospital, CB2 0QQ Cambridge, United Kingdom |
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| Both short-term and long-term intracranial pressure (ICP) monitoring is indicated for a number of neurological pathologies. The clinical gold standard for ICP monitoring is invasive and involves inserting a pressure sensor into the brain tissue or cerebral spinal fluid space. Such sensors can only be used for a limited time due to the risk of infection and sensor degradation. Our aim was to develop a method for long-term non-invasive ICP monitoring after the removal of invasive ICP sensor. Arterial blood pressure (ABP) and cerebral blood flow velocity (FV) signals were used as inputs to an artificial autoencoder neural network. The network was trained with invasively measured ICP. Following the training phase, the network's outputs were used for estimating ICP based on ABP and FV only. The method was verified on clinical data from 98 traumatic brain injury patients. The proposed procedure managed to recover ICP using FV and ABP measurements. The median value of the Pearson correlation between the recovered and the reference ICP signals was 0.7, and the root mean square error was 3.9 mmHg with an interquartile range of less than 5 mmHg. An additional feature of our algorithm is that it not only outputs an ICP estimate, but also provides a confidence level. |
DOI:10.12693/APhysPolA.146.349 topics: artificial neural networks (ANN), autoencoder, biomedical signal processing, intracranial pressure |