Identification of Gastric Cancer from Speckle Patterns |
| C.A. Andrade-Erasoa, M. Patiño-Velascoa, J. Vásquez-Lópeza, b, J. Leónc, G. Bolaños-Pantojad and M. Trivie
aGrupo de Óptica y Laser, Departamento de Física, Universidad del Cauca, Popayán, Colombia bDepartamento Morfología, Facultad de Ciencias de la Salud, Universidad del Cauca, Popayán, Colombia cCentro de Investigaciones en Ingeniería y Organizaciones, Grupo de Investigaciones en Ciencias Aplicadas, Universidad Autónoma de Bucaramanga, Bucaramanga, Colombia dGrupo de Física de Bajas Temperaturas, Departamento de Física, Universidad del Cauca, Popayán, Colombia eCentro de Investigaciones Ópticas (CONICET La Plata - CIC) and UID Optimo, Dpto. Ciencias Básicas, Facultad de Ingeniería, Universidad Nacional de La Plata, Casilla de Correo 3, 1897 Gonnet-La Plata, Argentina |
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| Speckle technique is based on the light intensity distribution randomly formed when a laser light is reflected on a rough surface, creating a pattern of illuminated grains (constructively) and dark (destructive) on scales of 1 μm. When the samples are displaced or deformed, the speckle pattern is altered. In this paper we present speckle patterns obtained from samples of gastric mucosa that is physically altered for the carcinogenesis process. Biopsies were studied with different diagnoses and were grouped according to the characteristics of speckle patterns. Speckle patterns were obtained by illuminating the samples with green laser. Morphological parameters of the speckle patterns reveal existence of 3 descriptors: the average grain size, hydraulic radius and the radio of the Weddel disc, which showed a high, intermediate and low value. The comparison shows agreement between the histopathological diagnosis and the values obtained by the speckle technique, making this technique emerge as a new classification system for quantitative diagnosis of precancerous lesions. |
| DOI: 10.12693/APhysPolA.121.62 PACS numbers: 78.68.+m, 42.87.-d, 87.50.W- |