Nanocargo-Delivery Platform for Targeted Drug Delivery in Biomedical Applications: Magnetic Gd2O3 Nanoparticles in Porous SiO2

L. Žida, V. Zeleňáka, A. Berkutovab, J. Szűcsováb, A. Zeleňákováb aPavol Jozef Šafárik University in Košice, Department of Inorganic Chemistry, Košice, Slovakia bPavol Jozef Šafárik University in Košice, Department of CondensedMatterPhysics, Košice, Slovakia

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We investigated nanocargo-delivery magnetic platform composed of spherical Gd2O3 particles, loaded together with cytostatic drug 5-fluorouracil (5-FU) in periodic mesoporous silica matrix. The system under study combined the advantages of high surface area and pore volume of mesoporous silica cargo with the advantages of magnetic separability and targeted drug delivery, provided by magnetic Gd2O3 nanoparticles. The sample was characterized by HRTEM (High-Resolution Transmission ElectronMicroscopy), PXRD (powder X-ray diffraction), elemental analysis, and magnetic measurements by MPMS apparatus. A conventional paramagnetic response was observed in the whole 5-330 K range with high magnetization about 90 emu/g at 50 000 Oe. Effective magnetic moment per formula unit 7.88 μB obtained at room temperature is close to theoretical value 7.94 μB. The released amount of 5-FU represented more than 90% of the loaded one.

DOI:10.12693/APhysPolA.137.773 topics: mesoporous silica, Gd2O3 nanoparticles, drug delivery, 5-fluorouracil, magnetic susceptibility