Development of pH Independent Cyclodextrin Capped Silica Hybrid as Nanocarrier |
| F. Tariq, U. Rafique
Fatima Jinnah Women University, Department of Environmental Sciences, 46000, Rawalpindi, Pakistan |
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| Porous silica base hybrids have great potential for useful application such as drug delivery due to their high stability and hydrophilicity. Silica hybrids also serve as an outstanding host for guest molecules after gatekeeper attachment under specific pH conditions. It is proposed that variations in pH (a measure of hydrogen ion concentration), acidic (< 7) or basic (> 7), strongly affects the hydrophilicity of silica materials. The present study is designed to prepare silica hybrid by adapting the sol-gel protocol, follows the functionalization with vanadium by mixing method. The functionalization of silica hybrid thus enhances and improves the hydrophilicity of material without pH dependence. The functionalized hybrid is further loaded with drug (cisplatin) and grafted with cyclodextrin (gatekeeper) to achieve control drug release from the carrier. The formation of synthesized product is confirmed by characterizing it through different analytical techniques such as the Fourier transform infrared and scanning electron microscopy. The Fourier transform infrared method confirms the development, modification, and grafting of loaded silica hybrid by the appearance of peaks at 956, 1637, 1109, and 3165 cm-1. Scanning electron microscopy image of the product clearly reveals irregular, non-porous scales particles with random dispersion of loaded drug. The activity (release) of the drug from loaded material can be investigated by dialysis membrane experiment for 72 h under dark and uncontrolled pH conditions. |
DOI:10.12693/APhysPolA.135.655 topics: silica hybrid, cyclodextrin, FTIR, SEM, cisplatin |