Optimization of fMRI Analysis of Speech Areas in Pre- and Postoperative Diagnostics

I. Karpiela, Z. Drzazgaa, P. Mazgaja, M. Drzazgab and A. Giec-Lorenzc aDepartment of Medical Physics, Institute of Physics, University of Silesia, Uniwersytecka 4, 40-007 Katowice, Poland bInstitute of Computer Science, University of Silesia, Bedzinska 39, 41-200 Sosnowiec, Poland c Helimed Diagnostic Imaging Sp. z o.o., Laboratory of Magnetic Resonance Imaging, Panewnicka 65, 40-760 Katowice, Poland

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Functional magnetic resonance imaging (fMRI) was used to characterize relevant functional areas adjacent to the tumor what has important implications for surgical intervention. The aim of our study was to evaluate the functional areas of Broca and Wernicke responsible for production and understanding the speech which are very important from the point of view patients quality life using different variants of analysis available in the SPM package. Brain activity imaging with FWE controlling seems to be more appropriate than this with un uncorrected thresholds in clinical diagnostic. However analysis in the SPM should be carried out with great care taking into consideration that results can be influenced by parameters used in statistical approaches.

DOI: 10.12693/APhysPolA.133.728 PACS numbers: 87.57.Nk, 87.61.Pk, 87.66.Ur