Novel Aminoketooxime Ligand and Its Cu(II) and Mn(II) Complexes: Synthesis, Characterization and Molecular Docking Studies |
| G. Gorgulua, M.B. Cicek b and B. Dede b
aFaculty of Education, Mehmet Akif Ersoy University, Burdur, Turkey bFaculty of Science and Arts, Süleyman Demirel University, Isparta, Turkey |
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| A novel ligand, N,N"-(4-methyl-1,2-phenylene)bis(2-(biphenyl-4-yl)-N'-hydroxy-2-oxoacetimidamide) (H2L) with its Cu(II) and Mn(II) complexes were synthesized in this study. All compounds synthesized were also characterized by 1H- and 13C-NMR, the Fourier transform: infrared, elemental analysis, inductively coupled plasma optical emission spectrometry, molar conductivity, magnetic susceptibility measurements and thermogravimetric analysis. Vascular endothelial growth factor-2 (VEGFR-2) and cyclooxygenase-2 (COX-2) inhibition is often used as a parameter for being a potent anticancer agent in docking studies. For this purpose, synthesized and characterized ligand was investigated by molecular docking study to test its inhibitory effect against angiogenic factors VEGFR-2 and COX-2. |
DOI: 10.12693/APhysPolA.133.309 topics: oxime, dinuclear complex, antiferromagnetic, docking, VEGFR-2, COX-2 |