Genotoxicity Study of Carbon Nanoforms using a Comet Assay |
| A. Paneka, A. Frączek-Szczypta b, E. Długoń b, M. Nocuń b, C. Paluszkiewicz a and M. Błażewicz b
aInstitute of Nuclear Physics, Polish Academy of Sciences, PL-31342 Krakow, Poland bAGH University of Science and Technology, Faculty of Materials Science and Ceramics, PL 30059 Krakow, Poland |
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| Carbon nanoforms due to their unique properties can be applied in many areas also in medicine. This article presents preliminary genotoxicity studies of electrospun carbon nanofibers (ECNF). This material, apart from its numerous applications, may also be a candidate for use in medical therapy and diagnostics. Polyacrylonitrile (PAN) nanofibers received in the electrospinning process were carbonized and thereafter subjected to oxidation treatment (ECNF-F). Both types of fibres were analyzed with regard to genotoxic influence on the fibroblast line cells using comet assay. Additionally, comet assay experiments were conducted on biocompatible carbon nanotubes with a hydrophilic surface. The results indicate the key role of the oxidation process in the functionalization of carbon nanoparticles intended for medical purposes. |
DOI: 10.12693/APhysPolA.133.277 PACS numbers: 87.85.jj, 87.14.gk, 61.48.De |