Elimination of Magnetic Nanoparticles with Various Surface Modifications from the Bloodstream in vivo |
| N. Tomasovicova a, I. Khmaraa,b, M. Koneracka a, V. Zavisova a, M. Kubovcikova a, I. Antal a, J. Kovac a, M. Muckova c and P. Kopcansky a
aInstitute of Experimental Physics, SAS, Watsonova 47, 040 01 Kosice, Slovakia bInstitute of Physics, Faculty of Sciences, P.J. Safarik University, Park Angelinum 9, 041 54 Kosice, Slovakia cHameln rds, Horna 36, 900 01 Modra, Slovakia |
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| The magnetic nanoparticles with the core diameter 10 nm stabilized by sodium oleate and bovine serum albumin in phosphate buffer have been modified by different biocompatible substances such as poly(ethylene glycol) (PEG), dextran (DEX), and polyvinylpyrrolidone (PVP). Prepared biocompatible magnetic fluids were characterized to obtain the particle size distribution using scanning electron microscopy and the dynamic light scattering method. To study the elimination of different modified magnetic nanoparticles from bloodstream, the biocompatible samples were applied intravenously to the mice bloodstream with further blood specimens collecting in given time intervals. Magnetic moment of the lyophilized blood samples was measured by SQUID magnetometer. Time dependence of magnetic moment of magnetic nanoparticles and magnetic nanoparticles modified by DEX, PEG and PVP normalized to the Fe3O4 showed that the circulation time of magnetic nanoparticles in the bloodstream depends on the substance used for modification. The unmodified magnetic nanoparticles were trapped by reticuloendothelial system within 1 h while magnetic nanoparticles modified by DEX, PEG and PVP circulated in blood up to 3 h. |
DOI: 10.12693/APhysPolA.131.1159 PACS numbers: 75.50.Gg, 75.50.Tt, 87.85.jj |