Effect of BSA Protein on the Contrast Properties of Magnetite Nanoparticles during MRI

O. Strbaka, M. Kubovcikova b, L. Baciak c, I. Khmara b, D. Gogola d, M. Koneracka b, V. Zavisova b, I. Antal b, M. Masarova d, A. Krafcik d, P. Kopcansky b, D. Dobrota e, and I. Frollo d aBiomedical Center Martin, Jessenius Faculty of Medicine in Martin, Comenius University in Bratislava, Mala Hora 4, 036 01 Martin, Slovakia bInstitute of Experimental Physics, SAS, Watsonova 47, 040 01 Kosice, Slovakia cFaculty of Chemical and Food Technology, STU, Radlinskeho 9, 812 37 Bratislava, Slovakia dInstitute of Measurement Science, SAS, Dubravska cesta 9, 841 04 Bratislava 4, Slovakia eDepartment of Medical Biochemistry, Jessenius Faculty of Medicine in Martin, Comenius University in Bratislava, Mala Hora 4, 036 01 Martin, Slovakia

Full Text PDF

The aim of the study was to establish whether there is a significant change in the MRI contrast of magnetite nanoparticles, after BSA protein binding on the surface of particles. The rationale is the applicability of this feature in clinical practice for the tracking of specific proteins which are often associated with various pathologies. Contrast agents could bind to this specific marker, with the change in MRI contrast indicating the presence of pathology. We found that changes in relative contrast acquired at low-field MRI offer potential for the differentiation of magnetite nanoparticles with and without BSA protein. However, the variations in the transverse relaxation time (T2) and transverse relaxivity (r2), acquired at high-field MRI, were too small to be applicable for biomedical applications.

DOI: 10.12693/APhysPolA.131.1102 PACS numbers: 87.61.-c, 75.75.Fk, 87.15.kp