Stability of Ferrous Fumarate in Medicaments for Women: Application of Mössbauer Spectroscopy
M. Kądziołka-Gaweł and M. Wojtyniak
Institute of Physics, Silesian University, Uniwersytecka 4, 40-700 Katowice, Poland
Received: October 5, 2015; In final form: March 22, 2016
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Determination of the iron state (Fe2+ or Fe3+) and content of iron in commercial pharmaceutical products containing ferrous fumarate FeC4H2O4 was made by the Mössbauer spectroscopy and X-ray fluorescence method. Also, influence of thermal treatment on stability of ferrous fumarate in selected medicaments has been investigated. The investigated samples were annealed in definite temperature: 373, 473, and 573 K for 5 h. Room temperature Mössbauer spectra of initial samples gave clear evidence that two phases of iron were presented. The major component was connected with ferrous fumarate with a contribution from ≈85% to ≈50%, depending on investigated medicaments. Ferrous fumarate was stable up to annealing temperature 473 K. Above this temperature significant oxidation of Fe2+ to Fe3+ was observed.

DOI: 10.12693/APhysPolA.129.1242
PACS numbers: 87.64.kx