Synthesis of Endogenous Compounds Labeled with 11C for Positron Emission Tomography
K. Kilian and A. Pękal
Heavy Ion Laboratory, University of Warsaw, L. Pasteura 5a, 02-093 Warsaw, Poland
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Among the β+ emitting isotopes, produced in medical cyclotrons, carbon-11 is promising radionuclide for labeling of biologically active compounds and tracking their distribution in living organism. Therefore aminoacids, carboxylic acids, fatty acids and amines have been widely used in assessing and staging of brain tumors (11C-methionine), prostate cancer (11C-choline, 11C-acetate) and neurological disorders (11C-labeled neurotransmitters). This paper reviews recent achievements in synthesis of endogenous substances labeled with 11C and presents our experience in 11C-methionine synthesis. Proposed protocol is a reliable tool for routine manufacturing in clinical applications and animal studies.

DOI: 10.12693/APhysPolA.127.1475
PACS numbers: 87.57.un