De Novo Designed Proteins - Perspective Materials for Nanotechnology
J. Grzyb
Laboratory of Biological Physics, Institute of Physics, Polish Academy of Sciences, al. Lotników 32/46, 02-668 Warsaw, Poland
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The paper explores the field of de novo protein design, as a source of material for effective hybrid nanostructures. Main design approaches, namely the intuitional and the computational strategy, are briefly overviewed. The achievements in the field are illustrated with several examples, starting from historical heme binding maquettes to novel non-natural enzymes. Separate paragraph covers the problem of designing peptides, which may act as anchor between biological and non-biological parts of nanostructures. The advantages of de novo designed proteins and still existing problems of the field are discussed.
DOI: 10.12693/APhysPolA.122.279
PACS numbers: 87.14.E-, 89.20.Bb