ACTA

Presence of Magnetic Fluids Leads to the Inhibition of Insulin Amyloid Aggregation

Z. Gazova^a, K. Siposova^{a, b}, M. Koneracka^a, A. Antosova^a, V. Zavisova^a, M. Kubovcikova^a, D. Fedunova^a, J. Bagelova^a, N. Tomasovicova^a, Z. Daxnerova^c and P. Kopcansky^a
^aInstitute of Experimental Physics, Slovak Academy of Sciences, Kosice, Slovakia
^bDepartment of Biochemistry, Faculty of Science, Safarik University, Kosice, Slovakia
^cInstitute of Biology and Ecology, Faculty of Science, Safarik University, Kosice, Slovakia

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Insulin amyloid aggregation caused serious problems in the treatment of diabetes by insulin injection or by insulin pumps. In vitro formation of insulin amyloid fibrils was investigated in presence of several types of magnetic fluids. Interaction of magnetic fluids with insulin amyloid aggregates led to decrease of insulin fibrillization. The inhibiting activities are affected by coating layer of studied magnetic fluids as well as by their physical properties (diameter, concentration of magnetic particles). The highest inhibiting efficiencies were detected for sterically stabilized magnetic fluids in saline solution (75%) and for magnetic fluids modified by dextran (80%).

DOI: 10.12693/APhysPolA.121.1305
PACS numbers: 87.14.em, 47.65.Cb, 87.85.jj