Structural Changes of DPPC Bilayers Induced by Gemini Surfactant |
| W. Kida, M. Kozak
Departament of Macromolecular Physics, Faculty of Physics, A. Mickiewicz University, Umultowska 85, 61-614 Poznań, Poland |
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| The phospholipid-gemini surfactant systems are promising agents for construction of lipoplexes for DNA delivery systems in gene therapy. In this work the influence of a gemini surfactant - 1,1'-(1,6-hexan)bis3-octyloxymethylimidazolium di-chloride) (IMI_Cl_C6_C8) on the structure and phase behaviour of aqueous suspensions of the fully hydrated phospholipid 1,2-dipalmitoyl-sn-glycero-3-phosphocholine (DPPC) were characterised using small angle scattering of synchrotron radiation (SAXS), differential scanning calorimetry (DSC) and Fourier transform: infrared spectroscopy (FTIR). The surfactant studied caused a destabilisation of the lamellar phase typical of DPPC. Addition of the surfactant also shifted to lower temperatures and extended the range of the main phase transition |
| DOI: 10.12693/APhysPolA.121.893 PACS numbers: 87.15.Zg, 61.05.cf, 87.64.km, 87.16.dt |