Mechanochemical Preparation of Organic-Inorganic Hybrid Materials of Drugs with Inorganic Oxides

T.P. Shakhtshneidera,b, S.A. Myza,b, M.A. Dyakonovaa,b, V.V. Boldyreva,b, E.V. Boldyrevaa,b, A.I. Nizovskii c, A.V. Kalinkin c and Rakesh Kumar d aInstitute of Solid State Chemistry and Mechanochemistry, Kutateladze str., 18, Novosibirsk, 630128, Russia bResearch and Education Center "Molecular Design and Ecologically Safe Technologies" at Novosibirsk State University, Pirogova str., 2, Novosibirsk, 630090, Russia cBoreskov Institute of Catalysis, pr. Lavrentieva, 5, Novosibirsk, 630090, Russia dNational Metallurgical Laboratory, Jamshedpur-831 007, India

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The nanocomposites of piroxicam and meloxicam with alumina were obtained by ball-milling as a result of distribution of the drugs at the surface of oxide with formation of the stable composites. The observed changes in the IR spectra of the ball-milled mixtures suggested the interaction of the drugs with the alumina active surface sites. The functional groups in molecules of piroxicam and meloxicam involved into formation of bonds between the drugs and the surface of the oxide were determined, they are amide, sulfate, enol groups, and pyridyl / thiazolyl nitrogen atoms. It appears that the formation of the new bonds at the contacts of particles in the composite leads to the stabilization of the drugs in metastable state inhibiting their transformation into initial crystalline form.

DOI: 10.12693/APhysPolA.120.272 PACS numbers: 62.25.-g