Thermal Analysis of Magnetic Polymer Nanospheres for Drug Targeting |
| A. Juríková, K. Csach, J. Miškuf, M. Koneracká, V. Závišová, and P. Kopčanský
Institute of Experimental Physics, Slovak Academy of Sciences, Watsonova 47, 040 01 Košice, Slovakia |
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| Poly(D,L-lactic-co-glycolic) acid (PLGA) polymer nanospheres loaded with different input amounts of anticancer drug taxol were prepared by the modified nanoprecipitation method. Magnetite was incorporated into the polymer nanospheres to impart them superparamagnetic properties. Thermal properties of the drug loaded magnetic polymer nanospheres were characterized using differential scanning calorimetry and thermogravimetric analysis. The solid state solubility of taxol in PLGA nanospheres and the influence of external magnetic field on their thermal stability were estimated. The investigations have revealed that the samples of dried taxol loaded magnetic PLGA nanospheres undergo mass loss at three stages during heating. |
| DOI: 10.12693/APhysPolA.118.990 PACS numbers: 47.65.Cb, 65.80.-g, 47.63.mh |