Molecular Interaction between Bacterial Antigens and Macrophage Receptors Studied by Atomic Force Microscopy

M. Targosza, P. Czubaa, R. Biedroń b, M. Strusc, A. Gamiand, J. Marcinkiewicz b and M. Szymońskia aInstitute of Physics, Jagiellonian University, Reymonta 4, 30-059 Kraków, Poland bInstitute of Immunology, Medical College, Jagiellonian University, Czysta 17, 31-121 Kraków, Poland cInstitute of Microbiology, Medical College, Jagiellonian University, Czysta 17, 31-121 Kraków, Poland dInstitute of Immunology and Experimental Therapy, Polish Academy of Sciences, Weigla 12, 53-114 Wrocław, Poland

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Received: 2005 20 05;

Atomic force spectroscopy was used to study interaction strengths between bacterial antigens and receptors on macrophages. This method allowed for a direct comparison of the interaction strengths in different systems studied at the level of single molecules.

DOI: 10.12693/APhysPolA.109.421 PACS numbers: 82.37.Rs, 87.64.Dz, 87.15.Kg