Effect of pH on Paramagnetic Centers in Cladosporium cladosporioides Melanin |
| B. Pilawaa, E. Buszmanb, A. Gondzika, S. Wilczyńskia, M. Zdybela, T. Witoszyńskab and T. Wilczokc
aDepartment of Medical Physics, School of Pharmacy, Medical University of Silesia, Narcyzów 1, 41-200 Sosnowiec, Poland bDepartment of Pharmaceutical Chemistry, School of Pharmacy, Medical University of Silesia, Jagiellońska 4, 41-200 Sosnowiec, Poland cDepartment of Molecular Biology and Medical Genetics, School of Pharmacy, Medical University of Silesia, Narcyzów 1, 41-200 Sosnowiec, Poland |
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| Received: 24 04 2005; |
| Paramagnetic centers in melanin existing in pigmented soil fungi Cladosporium cladosporioides cultured at acidic (4, 5, 6), neutral (7), and alkaline (8) pH were studied by EPR method. o-semiquinone free radicals (g: 2.0032-2.0040) concentration in melanin biopolymer increased for pH from 4 to 6, decreased at pH 7, and reached the maximum value at pH 8. It may be expected that melanin free radicals reactions with small molecules (metal ions, drugs) are the most effective at pH between 6 and 8. Slow spin-lattice relaxation processes exist in the all studied melanin samples. |
| DOI: 10.12693/APhysPolA.108.147 PACS numbers:61.66.Hq, 76.30.Rn |