Mutant HIV-1 Protease Complexed with Tetrapeptide Inhibitor. Preliminary Report
T. Skalovaa, J. Haseka, J. Dohnaleka, H. Petrokovaa and E. Buchtelovab
aInstitute of Macromolecular Chemistry AS CR Heyrovskeho nam. 2, 162 06 Prague 6, Czech Republic
bFaculty of Science, Charles University, Prague, Czech Republic
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The paper presents preliminary description of structure determination of a mutant form of HIV-1 protease in a complex with a new pseudotetrapeptide inhibitor that retains its high affinity to this mutant enzyme (A71V, V82T, I84V). A highly efficient microdiffractometer installed for our experiment at the beamline ID14-1 enabled us to collect satisfactory data with crystal dimensions of about 40 micrometers.
DOI: 10.12693/APhysPolA.101.659
PACS numbers: 87.15.By