Mutant HIV-1 Protease Complexed with Tetrapeptide Inhibitor. Preliminary Report |
| T. Skalovaa, J. Haseka, J. Dohnaleka, H. Petrokovaa and E. Buchtelovab aInstitute of Macromolecular Chemistry AS CR Heyrovskeho nam. 2, 162 06 Prague 6, Czech Republic bFaculty of Science, Charles University, Prague, Czech Republic |
| Full Text PDF |
| The paper presents preliminary description of structure determination of a mutant form of HIV-1 protease in a complex with a new pseudotetrapeptide inhibitor that retains its high affinity to this mutant enzyme (A71V, V82T, I84V). A highly efficient microdiffractometer installed for our experiment at the beamline ID14-1 enabled us to collect satisfactory data with crystal dimensions of about 40 micrometers. |
| DOI: 10.12693/APhysPolA.101.659 PACS numbers: 87.15.By |